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May 13, 2022

U.S. Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

 

Re:

Autolus Therapeutics plc

Registration Statement on Form F-3

File No. 333-264650

Acceleration Request

Requested Date:       May 17, 2022

Requested Time:      4:00 P.M. Eastern Time

Ladies and Gentlemen:

In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned registrant (the “Registrant”) hereby requests that the Securities and Exchange Commission take appropriate action to cause the above-referenced Registration Statement on Form F-3 (the “Registration Statement”) to become effective on May 17, 2022, at 4:00 p.m., Eastern Time, or as soon thereafter as is practicable, or at such later time as its counsel may orally request via telephone call to the staff. The Registrant hereby authorizes each of Darren DeStefano, Courtney Thorne and William DuVal of Cooley LLP, counsel to the Registrant, to make such request on its behalf.

Once the Registration Statement has been declared effective, please orally confirm that event with Darren DeStefano of Cooley LLP at (703) 456-8034, or in his absence, Courtney Thorne at (617) 937-2318. Thank you for your assistance with this matter.


Sincerely,
AUTOLUS THERAPEUTICS PLC
By:  

/s/ Christian Itin

  Christian Itin
  Chief Executive Officer
cc:   Alex Driggs, Autolus Therapeutics plc
  Darren DeStefano, Cooley LLP
  Christian Plaza, Cooley LLP
  Courtney Thorne, Cooley LLP